Offered to students admitted to Year 1 in ALL
Major/Minor ALL
Course Type
Offer in 2021 - 2022 Y N
Course Code BIOL4416
Date2022/01/20 06:38
Enquiry for Course Details
   <<< This course is not offered in 2021 - 2022. Course details are subject to change. >>>
BIOL4416 Stem cells and regenerative biology (6 credits) Academic Year 2021
Offering Department Biological Sciences Quota 40
Course Co-ordinator Dr K W Y Yuen, Biological Sciences < kwyyuen@hku.hk >
Teachers Involved (Dr Chaogu Zheng,Biological Sciences)
(Dr J Zhang,Biological Sciences)
(Dr K W Y Yuen,Biological Sciences)
Course Objectives To introduce the current understanding in regenerative biology, aging and longevity at the cellular and molecular level, and to present the interconnection between these biological events.
Course Contents & Topics The course will discuss cutting-edge research in
(i) regenerative and stem cell biology:
- the basic characteristics of stem cells
- the molecular and genetic control of cell fate specification and differentiation
- embryonic and adult stem cells
- experimental inducible pluripotent stem cells and tissue engineering
- therapeutics potentials for stem cell technology
- ethical issues in stem cell research
(ii) aging and longevity:
- model systems used for aging and life-span studies
- cellular and molecular biology of aging
- telomeres and cellular senescence
- genomic stability, DNA mutations and repair
- mitochondrial defects and oxidative stress
- genetic aging diseases
- genetic ,biochemical and metabolic pathways involved in longevity
Course Learning Outcomes
On successful completion of this course, students should be able to:

CLO 1 appreciate the complex regulations of cell potency, cell age and organism longevity
CLO 2 describe the characteristics of stem cells and the different types of stem cells
CLO 3 describe applications of stem cell research, and understand ethical concerns involved
CLO 4 describe the cellular mechanisms of aging, and the pathways involved in longevity
Pre-requisites
(and Co-requisites and
Impermissible combinations)
Pass in BIOC3601 or BIOC3604 or BIOL3211 or BIOL3401 or BIOL3402 or BIOL3403 or BIOL3404 or BIOL3408
Course Status with Related Major/Minor /Professional Core 2021 Major in Biological Sciences (Intensive) ( Disciplinary Elective )
2021 Major in Molecular Biology & Biotechnology ( Disciplinary Elective )
2021 Major in Molecular Biology & Biotechnology (Intensive) ( Disciplinary Elective )
2021 Minor in Molecular Biology & Biotechnology ( Disciplinary Elective )
2020 Major in Biological Sciences (Intensive) ( Disciplinary Elective )
2020 Major in Molecular Biology & Biotechnology ( Disciplinary Elective )
2020 Major in Molecular Biology & Biotechnology (Intensive) ( Disciplinary Elective )
2020 Minor in Molecular Biology & Biotechnology ( Disciplinary Elective )
2019 Major in Biological Sciences (Intensive) ( Disciplinary Elective )
2019 Major in Molecular Biology & Biotechnology ( Disciplinary Elective )
2019 Major in Molecular Biology & Biotechnology (Intensive) ( Disciplinary Elective )
2019 Minor in Molecular Biology & Biotechnology ( Disciplinary Elective )
2018 Major in Biological Sciences (Intensive) ( Disciplinary Elective )
2018 Major in Molecular Biology & Biotechnology ( Disciplinary Elective )
2018 Major in Molecular Biology & Biotechnology (Intensive) ( Disciplinary Elective )
2018 Minor in Molecular Biology & Biotechnology ( Disciplinary Elective )
2017 Major in Biological Sciences (Intensive) ( Disciplinary Elective )
2017 Major in Molecular Biology & Biotechnology ( Disciplinary Elective )
2017 Major in Molecular Biology & Biotechnology (Intensive) ( Disciplinary Elective )
2017 Minor in Molecular Biology & Biotechnology ( Disciplinary Elective )
Course to PLO Mapping 2021 Major in Biological Sciences (Intensive) < PLO 1,3,4 >
2021 Major in Molecular Biology & Biotechnology < PLO 1,3,4,5 >
2021 Major in Molecular Biology & Biotechnology (Intensive) < PLO 1,3,4,5 >
2020 Major in Biological Sciences (Intensive) < PLO 1,3,4 >
2020 Major in Molecular Biology & Biotechnology < PLO 1,3,4,5 >
2020 Major in Molecular Biology & Biotechnology (Intensive) < PLO 1,3,4,5 >
2019 Major in Biological Sciences (Intensive) < PLO 1,3,4 >
2019 Major in Molecular Biology & Biotechnology < PLO 1,3,4,5 >
2019 Major in Molecular Biology & Biotechnology (Intensive) < PLO 1,3,4,5 >
2018 Major in Biological Sciences (Intensive) < PLO 1,3,4 >
2018 Major in Molecular Biology & Biotechnology < PLO 1,3,4,5 >
2018 Major in Molecular Biology & Biotechnology (Intensive) < PLO 1,3,4,5 >
2017 Major in Biological Sciences (Intensive) < PLO 1,3,4 >
2017 Major in Molecular Biology & Biotechnology < PLO 1,3,4,5 >
2017 Major in Molecular Biology & Biotechnology (Intensive) < PLO 1,3,4,5 >
Offer in 2021 - 2022 N        To be confirmed Examination To be confirmed
Offer in 2022 - 2023 Y
Course Grade A+ to F
Grade Descriptors
A Demonstrate thorough and complete mastery at an advanced level of extensive knowledge and skills required for attaining all the course learning outcomes. Show strong analytical and critical abilities and logical thinking, with evidence of original thought, and ability to apply knowledge to a wide range of complex, familiar and unfamiliar situations. Apply highly effective organizational and presentational skills.
B Demonstrate substantial command of a broad range of knowledge and skills required for attaining at least most of the course learning outcomes. Evidence of analytical and critical abilities and logical thinking, and ability to apply knowledge to familiar and some unfamiliar situations. Apply effective organizational and presentational skills.
C Demonstrate general but incomplete command of knowledge and skills required for attaining most of the course learning outcomes. Evidence of some analytical and critical abilities and logical thinking, and ability to apply knowledge to most familiar situations. Apply moderately effective organizational and presentational skills.
D Demonstrate partial but limited command of knowledge and skills required for attaining some of the course learning outcomes. Evidence of some coherent and logical thinking, but with limited analytical and critical abilities. Show limited ability to apply knowledge to solve problems. Apply limited or barely effective organizational and presentational skills.
Fail Demonstrate little or no evidence of command of knowledge and skills required for attaining the course learning outcomes. Lack of analytical and critical abilities, logical and coherent thinking. Show very little or no ability to apply knowledge to solve problems. Organization and presentational skills are minimally effective or ineffective.
Course Type Lecture with laboratory component course
Course Teaching
& Learning Activities
Activities Details No. of Hours
Laboratory 24
Lectures 24
Tutorials 6
Reading / Self study 100
Assessment Methods
and Weighting
Methods Details Weighting in final
course grade (%)
Assessment Methods
to CLO Mapping
Assignments assignment/discussion 10 CLO 1,2,3,4
Examination 50 CLO 1,2,3,4
Laboratory reports 20 CLO 1,2,3,4
Test 20 CLO 1,2,3,4
Required/recommended reading
and online materials
References:
Essentials of stem cell biology
edited by Robert Paul Lanza 2009

Science in medicine: the JCI textbook of molecular medicine
By Andrew R. Marks, American Society for Clinical Investigation, Ushma S. Neill

Molecular biology of aging, Issue 51
By Leonard Guarente, Linda Partridge, Douglas C. Wallace - 2008
Course Website http://moodle.hku.hk/
Additional Course Information Offer in alternate year from 2017-2018
This course will be offered subject to a minimum enrollment number and availability of teachers.
Back  /  Home